Bioactive Small Molecules
Cayman Chemical CAY10717, Purity: ≥95%, CAS: 1240322-54-6, 25 mg
A multi-targeted kinase inhibitor; exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM; has activity at multiple oncogenic kinases (IC50 values less than 50 nM); highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM); inhibits the growth of HUVECs (EC50 = 34 nM)
Medchemexpress LLC (8R,9S)-Talazoparib ((8R,9S)-BMN-673) | 1207456-00-5 | 98.3% | 380.35 | 100 MG
(8R,9S)-Talazoparib is an enantiomer of Talazoparib and acts as a PARP1 inhibitor with an IC50 of 144 nM. This product is for research use only.
- Acts as a PARP-1 inhibitor with an IC50 of 144 nM.
- Exhibits an EC50 of 1135 nM for cytotoxicity against BRCA2-deficient human Capan1 cells.
- Shows an EC50 of 864 nM for inhibition of PARP in human LoVo cells.
- Demonstrates a GI50 of 1807 nM for potentiation of temozolomide-induced cytotoxicity in human LoVo cells.
- Displays an EC50 of 864 nM in cellular PARylation assay.
- Shows an EC50 of 1135 nM for Capan-1 cells (BRCA2 mutant).
Medchemexpress LLC PF-06928215 10mg | 2378173-15-8 | 10 MG
PF-06928215 is a small-molecule inhibitor of cyclic GMP-AMP synthase (cGAS) with a reported IC50 of 4.9 μM and a binding affinity (Kd) of 0.2 μM. It is supplied for research use as a high-purity solid with formula C20H20N4O4 and molecular weight 380.40 g/mol.
- Inhibits cGAS with reported IC50 of 4.9 μM.
- High binding affinity (Kd 0.2 μM).
- Chemical formula C20H20N4O4 and molecular weight 380.40 g/mol.
- High purity (99.7%) suitable for research use.
- Provided as a solid; typical pack size 10 MG.
Medchemexpress LLC IL-15 Human HEK293 20ug
Recombinant human interleukin-15 (IL-15) produced in HEK293 cells and supplied as a lyophilized, tag-free protein for research use. The preparation corresponds to residues N49-S162 of the human IL-15 sequence (accession P40933-1), is glycosylated, and is characterized for purity, endotoxin, and biological activity to support in vitro and cell culture assays. Store lyophilized at -20°C and follow recommended reconstitution and aliquoting procedures.
- Expressed in HEK293 cells for human-like post-translational modifications.
- Tag free and matches the native sequence (N49-S162).
- High purity (95% by reducing SDS-PAGE).
- Low endotoxin level (<1 EU/μg) suitable for cell-based assays.
- Verified biological activity (0.95 x 10^7 IU/mg).
- Lyophilized in PBS with 11% trehalose for enhanced stability.
- Stable frozen at -20°C; reconstitute at ≥100 μg/mL and aliquot for long-term storage.
eMolecules 7431-77-8 | Medchem Express | Sinapine (thiocyanate) | 10mg | 446275079 | HY-N0450 | 368.45 | C17H24N2O5S
Medchem Express | Sinapine (thiocyanate) | 10mg | 446275079 | HY-N0450 | 7431-77-8 | 368.450 | C17H24N2O5S
Cayman Chemical Tat (48-60) (trifluoroacetate salt), Purity: ≥95%, 5 mg
A peptide fragment of HIV Tat
Cayman Chemical Niclosamide (ethanolamine salt), Purity: ≥98%, CAS: 1420-04-8, 50 mg
A molluscicide; toxic to H. trivolvis snail eggs, juveniles, and adults (LC50s = 0.035, 0.044, and 0.11 mg/kg, respectively), as well as rainbow trout, white sucker, and fathead minnow (LC50s = 0.03, 0.09, and 0.11 mg/L, respectively); induces cell cycle arrest at the G0/G1 phase and induces apoptosis in DU145 cells in a concentration-dependent manner; inhibits STAT3-induced gene expression in a reporter assay using HeLa cells at 5 µM; uncouples mitochondria from respiration and increases the oxygen consumption rate of NIH3T3 fibroblasts at 1 µM; reduces blood glucose and plasma insulin levels, as well as decreases liver weight and triglyceride levels, in a mouse model of high-fat diet-induced diabetes in the diet at 1,500 ppm
TARGETMOL CHEMICALS INC INDISULAM 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Indisulam (E 7070) is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21 and inhibiting CDK2 causing a blockade in the G1/S transition. purity: 99%
Medchemexpress LLC 6-HEX | 50MG
6-HEX is one kind of light base group the wave length is 532 nm the wave length is 556 nm 6-HEX can be used to record nucleic acid sequences and design optical materials 6-HEX can be used to record nucleic acids at 543 nm radiation and at 550 nm and 650 nm radiation (5 nm radiation) it can be used to directly locate the base of the cell group[1][2]
Selleck Chemical LLC Panobinostat (LBH589) 50mg 404950-80-7 NVP-LBH589
Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical ML-145, Purity: ≥98%, CAS: 1164500-72-4, 1 mg
An antagonist of GPR35; inhibits zaprinast-, cromolyn-, or pamoic acid-induced β-arrestin recruitment in in HEK293 cells expressing the human receptor (EC50s = 26, 22, and 8.3 nM, respectively); inhibits constitutive and agonist-mediated IP1 accumulation in cells expressing human GPR35
TARGETMOL CHEMICALS INC FLLL32 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 uM). purity: 99%
Cayman Chemical RA-9, Purity: ≥98%, CAS: 919091-63-7, 5 mg
An inhibitor of deubiquitinating enzymes; inhibits UCH-L1, UCH-L3, and USP8 in a cell-free assay at 10 µM, as well as USP5 in a reporter assay at the same concentration; inhibits the 26S proteasome, but not the 20S proteasome, in a reporter assay using HeLa cancer cells at 10 µM; increases the levels of polyubiquitinated proteins in HeLa and TOV21G1 cancer cells at 5 µM; induces cell cycle arrest at the S and G2/M phases in HeLa cells at 10 µM; decreases the viability of nine cancer cell lines (IC50s= 1.64-12.49 µM); increases survival and decreases tumor and ascitic fluid mass in an ES-2 ovarian cancer mouse xenograft model at 5 mg/kg every other day
Apexbio Technology LLC Guanfacine hydrochloride 29110-48-3 50mg
Guanfacine hydrochloride (CAS 29110-48-3) is a selective agonist of the 2A-adrenergic receptor displaying approximately 60-fold selectivity over the 2B subtype (Kd 31 nM for 2A) Experimental studies indicate that low doses improve attention in NK1R knockout mice without affecting wild-type animals while higher doses suppress impulsivity in both genotypes In alcohol consumption models guanfacine reduces alcohol intake and attenuates alcohol deprivation effects in rats Additionally guanfacine modulates spinal nociceptive transmission through interactions with delta opioid receptors enhancing analgesic responses in nerve injury models These properties underscore its utility in studies of CNS function addiction and nociception
Medchemexpress LLC (±)-Leucine (DL-Leucine) | 328-39-2 | 99.95% | 100 G
(±)-Leucine, also known as DL-Leucine, is an isomer of the amino acid Leucine. It functions as both a chemosterilant and a dietary additive. Research indicates that this compound is effective in inhibiting bacterial growth, specifically demonstrating a 92.08% inhibition of Escherichia coli HfrH. Additionally, (±)-Leucine has been observed to enhance the average catch in certain applications by increasing the quantity of pheromone or the frequency of its production.
- Isomer of Leucine, also known as DL-Leucine or (RS)-Leucine.
- Functions as a chemosterilant and dietary additive.
- Demonstrates significant inhibitory activity against Escherichia coli HfrH (92.08% inhibition).
- Reported to increase average catch by influencing pheromone production.
- High purity of 99.95%.
- Comprehensive documentation, including Data Sheet and SDS, is available.